high-throughput methods to measure, predict, and modulate RNA interactions in cells
RNA structure chemical probing
We use DMS-MaPseq to probe RNA structures in vitro and in cells.
high-throughput designed RNA libraries
We systematically design RNA libraries to vary individual features of the RNA, linking changes in sequence to physical constants of RNA interactions.
thermodynamics of folding and binding
specificity and kinetics of RNA modifications
structure modulation using RNA therapeutics