high-throughput methods to measure, predict, and modulate RNA interactions in cells

RNA structure chemical probing

We use DMS-MaPseq to probe RNA structures in vitro and in cells.

high-throughput designed RNA libraries

We systematically design RNA libraries to vary individual features of the RNA, linking changes in sequence to physical constants of RNA interactions.

thermodynamics of folding and binding

specificity and kinetics of RNA modifications

structure modulation using RNA therapeutics

structure-based drug discovery